陈佩东

发布者:花文婷发布时间:2022-10-25浏览次数:10

职称:教授       E-mail:cpd@njucm.edu.cn      主要研究方向:中药活性成分与中药炮制机理研究


 

个人简介

        陈佩东,男,教授。现执教于cmd体育比赛官网中药化学教研室,从事中药化学、天然药物化学、波谱学等课程的教学,科研方向为中药活性成分及复方配伍机理、中药炮制和中药的质量标准等领域的研究。主持了国家自然科学基金面上项目及其他各级各类课题4项,发表论文20余篇,其中SCI 10余篇。在参与完成的多项课题中,获得多项奖项

 

承担的主要科研项目

1. 国家自然科学基金面上项目(81873001,基于VEGF-A通路PLCγ1-PI3K/Akt反馈机制的蒲黄炭化瘀止血炮制机理研究,2019/01-2022/12,主持,经费数57,在研

2. 国家自然科学基金面上项目(81573604,基于Na-K-ATP酶对津液“收敛固涩”探讨五味子“生熟异用”作用机制,2008/01-2010/12参与,经费数60结题。

3. 国家自然科学基金青年项目(3701108,醋蒸五味子炮制机理的研究,2019/01-2022/12参与,经费数23结题。

4. 中国药典会项目项目编号YD-108,蒲黄炭饮片质量标准研究,2009/01-2010/12主持,经费数5结题。

5. 江苏省中医院管理局项目,蒲黄炭炮制机理研究,2007/01-2010/12主持,经费数1结题。

6. 南京中医药大学风险基金项目,抗溃疡性结肠炎创新中药新药的研制(CX201202)2012/01-2014/12主持,经费数10结题。


代表性论文

1. Gao M, Lan J, Zha Y, Yao W, Bao B, Shan M, Zhang F, Zhou G, Yu S, Cheng F, Cao Y, Yan H, Zhang L*, Chen P*. Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Int J Biol Macromol. 2022S0141-8130(22)02231-0. doi: 10.1016/j.ijbiomac.2022.10.002.

2. Gao M, Lan J, Zhang Y, Yu S, Bao B, Yao W, Cao Y, Shan M, Cheng F, Zhang L*, Chen P*. Discovery of processing-associated Q-marker of carbonized traditional Chinese medicine: An integrated strategy of metabolomics, systems pharmacology and in vivo high-throughput screening model. Phytomedicine. 202,102:154152. doi: 10.1016/j.phymed.2022.154152.

3. Wei X, Gao M, Sheng N, Yao W, Bao B, Cheng F, Cao Y, Yan H, Zhang L, Shan M*, Chen P*. Mechanism investigation of Shi-Xiao-San in treating blood stasis syndrome based on network pharmacology, molecular docking and in vitro/vivo pharmacological validation. J Ethnopharmacol. 2022,301:115746. doi: 10.1016/j.jep.2022.115746.

4.Gao M#, Ge Z, Deng R, Bao B, Yao W, Cao Y, Shan M, Cheng F, Yan H, Chen P*, Zhang L*. Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product. J Ethnopharmacol. 2021,268:113591. doi: 10.1016/j.jep.2020.113591 

5. Gao M#, Lan J, Bao B, Yao W, Cao Y, Shan M, Cheng F, Chen P*, Zhang L*. Effects of carbonized process on quality control, chemical composition and pharmacology of Typhae Pollen: A review. J Ethnopharmacol. 2021,270:113774. doi: 10.1016/j.jep.2020.113774.  

6.Peidong Chen#, Yudan Cao, Beihua Bao, Li Zhang*, Anwei Ding. Antioxidant capacity of Typha angustifolia extracts and two active flavonoids, Pharm Biol. 2017 ,55(1):1283-1288. doi: 10.1080/13880209.2017.1300818..

7.Peidong Chen#, Shijia Liu#, Guoliang Dai, Liyan Xie, Jie Xu, Ling Zhou, Wenzheng Ju*, Anwei Ding. Determination of typhaneoside in rat plasma by liquid chromatography–tandem mass spectrometry,  J Pharm Biomed Anal. 2012,70:636-9. doi: 10.1016/j.jpba.2012.06.032.

8.Liu S#, Dai G, Sun L, Sun B, Chen D, Zhu L, Wang Y, Zhang L, Chen P*, Zhou D*, Ju W*. Biotransformation and Metabolic Profile of Limonin in Rat Liver Microsomes, Bile, and Urine by High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 2018,66(40):10388-10393. doi: 10.1021/acs.jafc.8b02057.

9. Liu S#, Wang Y, Liu H, Xu T, Wang MJ, Lu J, Guo Y, Chen W, Ke M, Zhou G, Lu Y*, Chen P*, Zhou W*. Serum lipidomics reveals distinct metabolic profiles for asymptomatic hyperuricemic and gout patients. Rheumatology (Oxford). 2022,61(6):2644-2651. doi: 10.1093/rheumatology/keab743. 

10.Peidong Chen#*, Xi Zhou, Li Zhang, Mingqiu Shan, Beihua Bao, Yudan Cao, An Kang, Anwei Ding. Anti-inflammatory effects of Huangqin Tang extract in mice on ulcerative colitisJ Ethnopharmacol. 2015,162:207-14. doi: 10.1016/j.jep.2014.12.039.

 

获得奖项与荣誉

2019,江苏中医药科学技术奖,代表性中药炭药炮制机理和质量标准研究,二等奖,江苏中医药科学技术委员会,排名第四。


其他成果

专利:

1. 一种用黄蜀葵秸秆制备塑木材料的方法,ZL 2013 1 0494845.6,陈佩东,段金廒,严辉,发明专利。

2.一种新型真空润药机 ZL2018 2 0741140.8,陈佩东,包贝华,程芳芳,单鸣秋,张丽,于生,曹雨诞,姚卫峰,石海培,实用新型专利。

3.一种黄芩汤颗粒治疗溃疡性结肠炎及其制备方法,ZL2014 1 0287583.0,陈佩东,发明专利。

4.一种厚朴去粗皮的加工装置,ZL 2015 2 0423481.7, 陈佩东,张丽,单鸣秋,包贝华,曹雨诞,丁安伟,实用新型专利。

教材:

天然药物化学,副主编,中国医药科技出版社,2021.




南中医cmd体育比赛官网南中医cmd体育比赛官网学子